Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair.
نویسندگان
چکیده
Myelin is essential for rapid and accurate conduction of electrical impulses by axons in the central and peripheral nervous system (PNS). Myelin is formed in the early postnatal period, and developmental myelination in the PNS depends on axonal signals provided by Nrg1/ErbB receptors. In addition, Nrg1 is required for effective nerve repair and remyelination in adulthood. We discuss here similarities and differences in Nrg1/ErbB functions in developmental myelination and remyelination after nerve injury.
منابع مشابه
Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System
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ورودعنوان ژورنال:
- Current topics in developmental biology
دوره 116 شماره
صفحات -
تاریخ انتشار 2016